Overall, many of the studies to date have been limited by use of two-dimensional measures of BMD as outcomes, such as those derived by dual-energy X-ray absorptiometry. In the current paper, the authors utilize pQCT in order to explore whether there are differences in the response of cortical versus trabecular bone, and how physical activity leads to improved bone health. In addition, the current Michalopoulou study indicates that typical amounts of physical exercise can impact bone health. While previous investigations of research interventions have proven benefit, these interventions may be cumbersome or expensive to implement. Therefore, it is interesting that the authors explored habitual physical activity instead, offering us a “real world” exploration of the association between exercise and bone.