Potential cytoskeletal targets of cysteine proteases during hypoxia/ischemia in proximal tubules. The basolateral membrane of the proximal tubules contains the subunits of Na+/K+-ATPase, which are linked to the actin cytoskeleton by ankyrin and spectrin. This forms a metabolically stable complex. Potential cytoskeletal targets of cysteine proteases during hypoxia/ischemia are shown. Ank, ankyrin; CAM, cell adhesion molecule; 4.1, protein 4.1. Figure reproduced with permission from Taylor & Francis (36).