It has also been shown that pretreatment with curcumin
reduces the unburned skin interspaces that develop to full necrosis
[48], and has a favorable effect on the irradiated wound healing
thus presenting a substantial therapeutic strategy for both
radiation-induced skin injuries [49] and laser-induced skin
wounds [50]. In a metabolic impaired wound healing model, curcumin
improves noevascularization and faster wound healing
and was effective both orally and topically [51]. Curcumin also
regulated TGF-b signaling and inducible nitric oxide synthase
levels to significantly accelerate healing of wounds with or without
dexamethasone treatment [45]. Angiogenesis, the formation
of new blood vessels play a pivotal role during wound healing
and curcumin acts as a proangiogenic agent during the critical
process of wound repair by regulating TGF-b [45]. Based on
these findings, it has been hypothesized that TGF-b1 might play
an important role in the enhancement of wound healing by curcumin
and indicate the beneficial effects of curcumin.