The influences of the thermostat temperature, gas flow rate, and residence time in the catalyst bed were experimentally examined and compared with the results obtained from numerical simu- lations. From pilot reactor study it was found that the lowest index of ethanol/raw ethylene consumption C = 1.7 kg/kg can be achieved when ethanol conversion is no less than 98% and ther- mostat temperature does not exceed 440 ◦ C. The catalyst exhibited good performance and stability in pilot experiments. With the vali- dated model of a single tube reactor and using the minimal number of tubes as the optimization criterion, the optimal characteristics and process parameters of industrial tubular fixed bed reactor for ethylene production from bioethanol at capacity 60,000 TPA have been determined.