Understanding nanoemulsification processes is of prime importance for the development of nanoparticulate systems. In the formulation of nanocosmetics, homogenization appears to be the favored method of preparation of the cosmetic matrix in order to reduce the size of emulsion. The use of a mixture design approach appears to be a valuable tool in the investigation of real cosmetic matrix systems consisting of multiple ingredients, the proportions of which, in the mixture, are interrelated. Stable nanoemulsions containing an appropriate amount of emulsifiers were successfully formulated. Different physicochemical properties of nanoemulsions were measured such as size distribution, mobility, electrophoretic mobility, HLB, turbidity and melting point. The optimal formulation was calculated using a Nemrod software according to these physicochemical properties. This study indicates the influence of formulation on physicochemical properties of each nanoemulsion obtained by the mixture design.