seems to work equally well with methanol or ethanol, neither of which seems to interfere with
the reaction. The use of other solvent systems, such as almost neat extracts in water or acetone, seems to give low values for the extent of reduction (Guo et al., 2001).
Regarding the pH level, in the original Blois paper it was suggested that the system should be
maintained at a pH in the range 5.0 to 6.5 by using acetate buffers; however, this precaution seems to have been abandoned in current practice. Indeed here is great uncertainty in the meaning of pH
values in these predominantly organic (methanolor ethanol) media
seems to work equally well with methanol or ethanol, neither of which seems to interfere with
the reaction. The use of other solvent systems, such as almost neat extracts in water or acetone, seems to give low values for the extent of reduction (Guo et al., 2001).
Regarding the pH level, in the original Blois paper it was suggested that the system should be
maintained at a pH in the range 5.0 to 6.5 by using acetate buffers; however, this precaution seems to have been abandoned in current practice. Indeed here is great uncertainty in the meaning of pH
values in these predominantly organic (methanolor ethanol) media
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