Lutz et al. (2005) tested whether HSs can interfere with endocrine
regulation in the amphibian Xenopus laevis Daudin. The
in vivo results showed significant estrogenic effects on X. laevis
during its larval development and resulted in a marked increase
of the estrogenic biomarker estrogen receptor mRNA (ER-mRNA).
Furthermore, the thyroid-stimulating hormone (TSHb-mRNA) is
enhanced after exposure to HS1500, indicating a weak adverse effect
on T3/T4 availability