. Peroxynitrite, the
product of the reaction between superoxide and nitric oxide, in
particular, interacts with lipids, DNA, and proteins via direct
oxidative reactions or via indirect, radical-mediated mechanisms
[12]. These reactions trigger cellular responses ranging from subtle
modulations of cell signaling to overwhelming oxidative injury,
committing cells to necrosis or apoptosis. The understanding of the
molecular mechanisms underpinning both hyperoxia and hypoxia
is still emerging