The assumption has been that these poor outcomes are the result of inadequately controlled intra-articular bleeding in patients with inhibitors. However, a prospective study of patients with hemophilia and inhibitors has reported joint and other types of bleeds at lower frequencies than those described in some studies of patients without inhibitors.Additional factors that might contribute to these outcomes include comorbidities and high-intensity treatment and are discussed later.The purpose of this paper is to review the major psychosocial challenges faced by adult patients with inhibitors where such data exist, to describe the need for psychosocial data specific to patients with inhibitors, and to suggest psychosocial intervention strategies for patients dealing with the challenges of hemophilia with inhibitors.