Objective To assess, by socioeconomic setting, the effect of nationwide vaccination against species A rotavirus (RVA) on childhood
diarrhoea-related hospitalizations in Mexico.
Methods Data on children younger than 5 years who were hospitalized for diarrhoea in health ministry hospitals between 1 January
2003 and 31 December 2011 were collected from monthly discharge reports. Human development indexes were used to categorize the
states where hospitals were located as having generally high, intermediate or low socioeconomic status. Annual rates of hospitalization
for diarrhoea – per 10 000 hospitalizations for any cause – were calculated. Administrative data were used to estimate vaccine coverage.
Findings In the states with high, intermediate and low socioeconomic status, coverage with a two-dose monovalent RVA vaccine –
among children younger than 5 years – had reached 93%, 86% and 71%, respectively, by 2010. The corresponding median annual rates of
hospitalization for diarrhoea – per 10 000 admissions – fell from 1001, 834 and 1033 in the “prevaccine” period of 2003–2006, to 597, 497
and 705 in the “postvaccine” period from 2008 to 2011, respectively. These decreases correspond to rate reductions of 40% (95% confidence
interval, CI: 38–43), 41% (95% CI: 38–43) and 32% (95% CI: 29–34), respectively. Nationwide, RVA vaccination appeared to have averted
approximately 16 500 hospitalizations for childhood diarrhoea in each year of the postvaccine period.
Conclusion Monovalent RVA vaccination has substantially reduced childhood diarrhoea-related hospitalizations for four continuous years
in discretely different socioeconomic populations across Mexico.
Objective To assess, by socioeconomic setting, the effect of nationwide vaccination against species A rotavirus (RVA) on childhooddiarrhoea-related hospitalizations in Mexico.Methods Data on children younger than 5 years who were hospitalized for diarrhoea in health ministry hospitals between 1 January2003 and 31 December 2011 were collected from monthly discharge reports. Human development indexes were used to categorize thestates where hospitals were located as having generally high, intermediate or low socioeconomic status. Annual rates of hospitalizationfor diarrhoea – per 10 000 hospitalizations for any cause – were calculated. Administrative data were used to estimate vaccine coverage.Findings In the states with high, intermediate and low socioeconomic status, coverage with a two-dose monovalent RVA vaccine –among children younger than 5 years – had reached 93%, 86% and 71%, respectively, by 2010. The corresponding median annual rates ofhospitalization for diarrhoea – per 10 000 admissions – fell from 1001, 834 and 1033 in the “prevaccine” period of 2003–2006, to 597, 497and 705 in the “postvaccine” period from 2008 to 2011, respectively. These decreases correspond to rate reductions of 40% (95% confidenceinterval, CI: 38–43), 41% (95% CI: 38–43) and 32% (95% CI: 29–34), respectively. Nationwide, RVA vaccination appeared to have avertedapproximately 16 500 hospitalizations for childhood diarrhoea in each year of the postvaccine period.Conclusion Monovalent RVA vaccination has substantially reduced childhood diarrhoea-related hospitalizations for four continuous yearsin discretely different socioeconomic populations across Mexico.
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