Consistent with interventions to prevent diabetes, recommendations to manage type 2 diabetes in overweight and obese people focus on lifestyle modifications that lead to weight loss—namely, a lower calorie intake, healthy food choices, and increased physical activity. Short-term studies show that moderate weight loss (5% of body weight) in people with type 2 diabetes improves insulin resistance, glycemic control, lipid levels, and blood pressure. However, many patients have unsuccessfully tried to lose weight even before being diagnosed with diabetes, and achieving long-term weight loss is difficult for most people. If lifestyle modifications fail to produce weight loss, additional weight loss strategies may be considered. Weight loss medications, when combined with a healthy diet and exercise, can promote a 5% to 10% weight loss. Drug labels state that the medications should only be used in people with diabetes who have a body mass index (BMI) >27 (Bantle et al., 2008).