In the second half of the last century, there was intensive development of the taiga regions of Primorsky Krai. Mining operations were actively conducted in remote areas of the taiga, which were previously considered unreachable. Three mining fields were developed near the modern boundaries of the Sikhote-Alin State Nature Reserve. Development of the Lysogorskiy tin deposit located on the main watershed of Sikhote-Alin begun with excavations on the western slope. Only one tunnel was located on the eastern slope within the current territory of the reserve. At the present time, the territory of the mine is located within the protective zone of the reserve. Another tin deposit, Tayozhniy, was located near the northern boundaries of the reserve. It was named after the settlement next to which it was founded. These tin deposits, located on the western spurs of the Sikhote-Alin, were in operation until the 1990s, with hundreds of millions of cubic metres of processed rock changing the look of vast territories and violating the hydrological regime of water bodies. However, the greatest anthropogenic stress was experienced by small streams that drained the territory of mining and processing, which were not protected from salted drainage water from the tunnels and tailings. The gold and silver mining complex Serebryaniy, located at the eastern boundary of the reserve, was built in the late 1980s with all accessible contemporary technology that restricted the flow of mine drainage water into streams. Since 1995, the Serebryaniy mining complex was operated occasionally and was finally sealed off at the end of 2012. Biological indices obtained by us for the watercourses draining the territory of these mines showed that over time certain changes occurred in the structure of zoobenthos (Potikha, 2012 and Potikha and Zorina, October 23–27 2006) in relation to the watercourses of the Sikhote-Alin Nature Reserve (Potikha, 2011).