It can be observed that the addition of increasing concentrations
of antioxidants to the plasma induced a decrease in the
sensor response (DE) (Fig. 2A, B, and C). The x variable is presented
as the log of antioxidant concentrations, obeying the Nernst equation
[17]. The addition of these antioxidants, alone or in synergy
with the antioxidant system [16], increases the ability of plasma
to donate electrons to oxidation reactions at lower potentials. This
decrease in DE correlates directly with the concentrations of ascorbate
(2.575.0 lmol/L; R = 0.99), urate (9.0150.0 lmol/L;
R = 0.99), and bilirubin (0.7813 lmol/L; R = 0.99) that were
used.
Fig.