Background & aims: This study was carried out to evaluate the effects of omega-3 fatty acid administration
on markers of insulin resistance, lipid concentrations, biomarkers of inflammation and oxidative
stress in patients with diabetic nephropathy (DN).
Methods: This parallel randomized double-blind placebo-controlled clinical trial was performed among
60 patients with DN. Patients were randomly allocated into two groups to receive either 1000 mg/day
omega-3 fatty acid from flaxseed oil (n ¼ 30) or placebo (n ¼ 30) for 12 weeks. Fasting blood samples
were taken at the onset of the study and 12 weeks after supplementation to assess glycaemic status, lipid
concentrations, biomarkers of inflammation and oxidative stress.