“Oxidativestress” as aconceptinredo

“Oxidativestress” as aconceptinredoxbiologyandmedicinehasbeenformulatedin1985;atthebe-
ginning of2015,approx.138,000PubMedentriesshowforthisterm.Thisconcepthasitsmeritsandits
pitfalls. Amongthemeritsisthenotion,elicitedbythecombinedtwotermsof(i)aerobicmetabolismas
a steady-stateredoxbalanceand(ii)theassociatedpotentialstrainsinthebalanceasdenotedbythe
term, stress,evokingbiologicalstressresponses.Currentresearchonmolecularredoxswitchesgov-
erning oxidativestressresponsesisinfullbloom.Thefundamentalimportanceoflinkingredoxshiftsto
phosphorylation/dephosphorylation signalingisbeingmorefullyappreciated,thankstomajoradvances
in methodology.Amongthepitfallsisthefactthattheunderlyingmoleculardetailsaretobeworkedout
in eachparticularcase,whichisbviousforaglobalconcept,butwhichissometimesoverlooked.Thiscan
lead toindiscriminateuseoftheterm,oxidativestress,withoutclearrelationtoredoxchemistry.The
majorroleinantioxidantdefenseisfulfilled byantioxidantenzymes,notbysmall-moleculeantioxidant
compounds. The field ofoxidativestressresearchembraceschemistry,biochemistry,cellbiology,phy-
siology andpathophysiology,allthewaytomedicineandhealthanddiseaseresearch.

ผลลัพธ์ (ไทย) 2:

"Oxidativestress" เป็น aconceptinredoxbiologyandmedicinehasbeenformulatedin1985; atthebe-
of2015 Ginning, approx.138,000PubMedentriesshowforthisterm.Thisconcepthasitsmeritsandits
ข้อผิดพลาด Amongthemeritsisthenotion, elicitedbythecombinedtwotermsof (i) aerobicmetabolismas
คง stateredoxbalanceand (ii) theassociatedpotentialstrainsinthebalanceasdenotedbythe
ระยะความเครียด evokingbiologicalstressresponses.Currentresearchonmolecularredoxswitchesgov-
erning
signalingisbeingmorefullyappreciated, thankstomajoradvances
ใน methodology.Amongthepitfallsisthefactthattheunderlyingmoleculardetailsaretobeworkedout
ใน eachparticularcase, whichisbviousforaglobalconcept, butwhichissometimesoverlooked.Thiscan
นำ
byantioxidantenzymes, notbysmall-moleculeantioxidant
สารประกอบ ofoxidativestressresearchembraceschemistry ข้อมูลชีวเคมี cellbiology, phy-
siology andpathophysiology, allthewaytomedicineandhealthanddiseaseresearch

ผลลัพธ์ (ไทย) 3:

" oxidativestress " เป็น aconceptinredoxbiologyandmedicinehasbeenformulatedin1985 ; atthebe -

approx.138000pubmedentriesshowforthisterm of2015 ginning , . thisconcepthasitsmeritsandits ข้อผิดพลาด amongthemeritsisthenotion elicitedbythecombinedtwotermsof , ( ผม ) aerobicmetabolismas
เป็น stateredoxbalanceand มั่นคง ( 2 ) theassociatedpotentialstrainsinthebalanceasdenotedbythe
เทอม , ความเครียดevokingbiologicalstressresponses . currentresearchonmolecularredoxswitchesgov -
erning oxidativestressresponsesisinfullbloom . thefundamentalimportanceoflinkingredoxshiftsto
ฟอสโฟริเลชัน / ดีฟอ ฟริเลชัน signalingisbeingmorefullyappreciated thankstomajoradvances
, งานวิจัย amongthepitfallsisthefactthattheunderlyingmoleculardetailsaretobeworkedout ใน eachparticularcase
,whichisbviousforaglobalconcept butwhichissometimesoverlooked , . thiscan
oxidativestress toindiscriminateuseoftheterm , ตะกั่ว , withoutclearrelationtoredoxchemistry .
majorroleinantioxidantdefenseisfulfilled byantioxidantenzymes notbysmall moleculeantioxidant
, สารประกอบ สนาม ofoxidativestressresearchembraceschemistry , ชีวเคมี , cellbiology siology andpathophysiology phy -
, ,allthewaytomedicineandhealthanddiseaseresearch .