Taken together, we provide evidence-base results here to show that CE could improve physical-induced fatigue and elevate exercise performance in mice, as shown in the Supplementary material. CE could ameliorate exercise-related increases in levels of biomarkers such as lactate and ammonia. It could decrease CK level, a muscle injury biomarker. It could elevate exercise performance by increasing tissue glycogen content. As well, CE could be supplemented with optimized and reasonable doses for physiological benefits. Excess doses could cause potential risk of renal loading with 28 days supplementation.