All patients were treated with biotin. Urine organic acids analysis (GC/MS) for 3-hydroxizovaleric acid was used for patients' monitoring. Neurological, audiological and ophthalmological evaluation has been conducted once a year.
All patients were treated with biotin. Urine organic acids analysis (GC/MS)for 3-hydroxizovaleric acid was used for patients' monitoring. Neurological, audiological and ophthalmologicalevaluation has been conducted once a year.