The anthophyte hypothesis seemed to be supported by some morphological, anatomical and reproductive characters, such as net-veined leaves, vessels in the wood, double fertilization and the simple, unisexual, flower-like structures, but later studies revealed that these character similarities between Genetales and angiosperms studies. Moreover, this hypothesis has been questioned by most molecular studies. Although angiosperms and Genetales were grouped together in several studies using ribosomal DNA or the third codon of the PHY gene, the results were very weakly supported statistically, and could be caused by some limitations of ribosomal DNA such as many paralogous copies b or the subtitutional saturation in PHY. Nevertheless, it remains interesting that the anthophyte hypothesis is supported by the slowly-evolving ribosomal DNA. In particular, found bias against recovering the anthophyte hypothesis in the molecular data.