Nanotechnology is a rapidly growing interdisciplinary area of science and technology that
integrates materials science and biology [1]. There is an immense interest in biomedicine
applications of nanoparticles owing to their size and structural similarity with biological
molecules. Antibiotic evasion by multidrug resistant bacteria and the almost negligible discovery
rate of novel antibiotics has forced the exploration of possible alternatives. Establishment of a
bacterial infection as a biofilm, a complex three-dimensional, attached bacterial community,
protects the bacteria from therapeutic agents and host defences, with potentially devastating
consequences for patient morbidity and mortality [2]. Biofilms are implicated in over 80 % of
bacterial infections as well as treatment related infections in the body [3]. The protection offered
by biofilms arises from multiple mechanisms, including a greater number of persistent cells,
quorum sensing systems, biosorption, gene expression response and efflux systems. Limited mass