The expression of HMGA proteins is usually low or absent in
most of normal adult tissues; however, overexpression of HMGA
proteins has been observed in several human malignancies and
has been found to correlate with occurrence of metastasis and
poor prognosis. Moreover, transgenic mice overexpressing either
HMGA1 or HMGA2 develop lymphoma and pituitary adenomas,
which strongly suggest oncogenic property of these proteins