Intradermal temperature normalises within a matter of seconds to a few minutes, yet the
benefits of even delayed cooling persist, implying it is not simply the removal of thermal
energy from the damaged tissues. Animal models have used oedema formation, preserva-
tion of dermal perfusion, healing time and hair retention as indicators of burns severity, and
have shown cooling to improve these indices, but pharmacological or immunological
blockade of humoural and cellular mediators of inflammation did not reproduce the benefit
of cooling.
Intradermal temperature normalises within a matter of seconds to a few minutes, yet thebenefits of even delayed cooling persist, implying it is not simply the removal of thermalenergy from the damaged tissues. Animal models have used oedema formation, preserva-tion of dermal perfusion, healing time and hair retention as indicators of burns severity, andhave shown cooling to improve these indices, but pharmacological or immunologicalblockade of humoural and cellular mediators of inflammation did not reproduce the benefitof cooling.
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