The issue of age is particularly important in the case of GM volume. In most brain regions, GM is lost more rapidly during the first six decades of life, followed by a subsequent slower decline (Sowell et al., 2003). The age effect is likely to be the dominant factor for GM changes in early and midadulthood. In late adulthood, however, most of the normal age-associated GM decline has occurred although the interindividual variation in GM remains. The present study was carried out to investigate GM, WM, and CSF volume in relation to personality in the later life.