4. Nature of Dietary Fat
As noted above, in animal studies, intake of saturated
fatty acids, monounsaturated and polyunsaturated fatty
acids except for the n-3 fatty acids, led to insulin resistance
when consuming a high-fat diet (3). Epidemiological studies
suggested that high intake of saturated fat is associated
with the risk of IGT and increased fasting glucose and insulin
levels (57). The higher proportion of saturated fatty acids
in serum lipids or phospholipids in muscles associated
with higher fasting insulin levels would reduce insulin
sensitivity (58, 59) and increase the risk of type 2 diabetes
(