The relationship of coffee with health has been featured in more than 8000 professional medical studies during the past 40 years. However, in many cases, conflicting findings and concerns have arisen, making it difficult for health professionals and the public to interpret the data. Coffee consumption tends to attract tobacco smoking, but many studies did not account for this potential confounding the data analysis. Some measurement errors seem to be inevitable in the assessment of coffee consumption, because people consume a wide variety of coffee from day to day. Coffee intake is determined by the size of the coffee cup and the strength of the brew as well as frequency of consumption. Despite 20 years of reassuring research, many people still avoid caffeinated coffee because they worry about the biological effects of caffeine. What is the conclusion of so much attention? We have thought that coffee is good for your health when consumed in moderation.Harvard Women’s Health Watch (2004) reported that current research reveals that in moderation coffee is a safe beverage that may even offer some health benefits. However, it is also emphasized that difficulties and challenges in designing a solid experiment or clinical trials to elucidate the effects of coffee on human health are present.