According to proposed by us the consequence of events in
atherosclerosis, intracellular lipid accumulation induced by modi-
fied LDL should be considered as the crucial event of atherogenesis.
Lipid accumulation stimulates the major atherosclerotic manifestations,
atthe same time associates of modified LDL destroy cellular
network in the intima by stimulating phagocytosis. This leads to the
formation of pronounced lipid-rich lesions, namely, fatty streaks
or fibrolipid plaques, where the intensity of atherogenic manifestations
at the cellular level shows the maximum.