A lifestyle intervention promoting reduced caloric intake and increased physical activity found
comparable weight loss across FTO genotypes at follow-up (5). Such a finding is supported
by our results, in that genetically predisposed obese individuals are responsive to weight loss
promoting exposures. However, our study focused only on the delivery of moderate intensity
exercise in a controlled manner, whereas caloric restriction was the predominant focus of the
lifestyle intervention described by Lappalainen et al. (5). While FTO risk variants have been
associated with increased caloric intakes (3), treating obesity through reducing caloric intake
alone would not additionally improve CRF.