3. Effect of curcumin on cardiovascular disease
Curcumin is an inhibitor of p300 histone acetyltransferase
activity, which is associated with heart failure [17]. Sunagawa et al.
reported that at a dosage of 50-mg/kg native curcumin prevented
deterioration of the systolic function in rat models of heart failure
[18]. To achieve more efficient oral pharmacological effects against
heart failure using curcumin, the authors estimated the dose
effects of Theracurmin in the same rat models of heart failure.