The studies have showed that the use of broad spectrum
sunscreen, UVA and UVB 13,14 associated with bleaching
creams is the fundamental basis for the treatment of melasma.
The hydroquinone has showed as the most effective and safe
isolated agent and with few adverse effects, both in treatment
and in preparation of the skin to physical or chemical
peelings15,40,42-44,47-48,53. The isolated use of retinoic acid is able
to reduce the melasma but in high concentrations, it can
cause undesirable results.16-18 The effect of hydroquinone and
retinoic acid is aggravated when used in combination with
corticosteroids, demonstrating greater efficiency and lower
total cost of treatment.19