We have found that the outliers and the imbalanced data directly affected the classification performance and effectiveness of the classifiers. There are 147 registers with PD and 48 healthy ones. The accuracy of the classifiers will be improved by eliminating a number of outliers from both the minority and majority classes, and increasing the size of the minority class to the same size of the majority class.
Once the AI methods have been separately and/or individually tested, the next step will be to use a clustering method also called a metalearning. Metalearning algorithms take classifiers and turn them into more powerful learners with a higher generalization degree. They carry out the classifications either by averaging probability estimation or by voting and they always take advantage of every particular method