However, the disadvantages of this process are the limited amount of nanoparticles loaded in the final formulation, time-consuming procedure, and possible incompatibilities with the ingredients existing in the dermal carriers such as viscosity enhancer in gel or surfactants/oils in cream. Therefore, to avoid such drawbacks, the production of a one-step process of the SLN formulations with semi-solid consistency through the usage of high lipid concentration would be favorable. Nevertheless, the dispersion nonhomogeneity induced by lipid aggregation could occur (Lippacher et al., 2004).