Levels of calcium and magnesium in the plasma usually decrease when receiving chemotherapy; therefore, these levels are used as the hematological index in patients with peripheral neuropathy. In this study, the levels of calcium and magnesium in the plasma did not show a significant change before or after treatment in either group, although they did show a tendency to decrease within the reference range. This could be interpreted as a positive effect of foot bathing or massage, but patients cannot expect physiological changes. Previous studies showed that oral or intravenous administration of calcium and magnesium reduced symptoms, preventing peripheral neuropathy. Thus, when undergoing long-term chemotherapy, supplementary calcium and magnesium appear to be a necessary addition to nonpharmacologic intervention.