This rise is mediated through inhibition or the renal transporter not been OCT-2, but the reduced creatinine secretion does not trans sis, there late into a lower glomerular filtration rate Elevations in r transaminases occur in S are generally mild, and occur at a iksaavia, similar rate as with raliegravir,darunavir ritonavir, and efa tunavir virena In the tunited number orpatients with hepatitis B or lpivirine C coinfection, the incidence of transaminase elevation rises bribed to to 16% most likely reflecting immune reconstitution, and is lower than that observed with raltegravir and efavirenz, ed lower but higher than that with darunavir ritonavir Elevation im pared to total cholesterol, low density lipoprotein, and triglycerides was no observed with PIs is absent with dolutegravir Creatine ents nor kinase elevations are common, largely asymptomatic, and discon- mild, with only 5% being grade lll or IV in severity with an Hypersensitivity reactions were extremely uncommon. f of the occurring in less than 1%, and tend to occur shortly after profile treatment initiation.