Garcinia mangostana L (mangosteen) is a natural raw materials of exogenous sources of antioxidants has been investigated in vitro. Amongst colorful fruits rich in anthocyanins (phenolic compounds), mangosteen rind is known to contain the family of bioactive xanthones that can inhibit the activities of unpaired electrons in free radicals by donating H (hydrogen) atoms.10 In vitro study showed that xanthone compounds, α-mangostin, promote strong antimicrobial activity against Propionibacterium acnes11 and other study showed its anti-inflammatory effect.12 This study was aimed to evaluate the efficacy of mangosteen rind extract given orally in term of clinical effectiveness as well as its influence on oxidative stress parameter.