Depression severity was assessed using the 17-item
version of the Hamilton Depression Rating Scale (HDRS-17) for all subjects with MDD and
BPD [23]. Manic symptoms were assessed by the YoungMania Rating Scale (YMRS) [24] for all
subjects with BPD. Based on the definition of remission determined by the International Society
for Bipolar Disorders Task Force [25], subjects with BPD whose YMRS total scores were 8 or
over were considered to be suffering from a significant manic state and excluded from this study.