Although data from animal studies have identified the respiratory tract as the major target organ for chronic chromium exposure, these data do not demonstrate that the effects observed following inhalation of chromium (VI) particulates are relevant to inhalation of chromium (III). (8)
EPA has not established an RfC for chromium (III). (8)
The RfD for chromium (III) is 1.5 mg/kg/d based on the exposure level at which no effects were observed in rats exposed to chromium (III) in the diet. (8)
EPA has low confidence in the RfD based on: low confidence in the study on which the RfD for chromium (III) was based due to the lack of explicit detail on study protocol and results; and low confidence in the database due to the lack of high-dose supporting data. (8)