Gold nanoparticles are get medical attention because 1) Biocompatibility and 2) a chemical bond with the drug. Or substances like lead into the body. However, there are limits in the gold nanoparticles 1) the toxicity of gold nanoparticles and 2) half-life of gold nanoparticles, dependence the size, shape, ligends, and charge surface. The effects of gold nanoparticles in various fields such as gold nanoparticles that interact with cell membranes. Or biomolecules in the body of an organism. It describes, in terms of size (size), shape (shape) ligand-coated surfaces. (Coat-ligands) and surface charge (surface charge) can be concluded that (1) to move into the cells, the nanoparticles of gold will depend on the size, shape, ligand-coated surfaces. And surface charge (2) ligands acting coating on the surface of gold nanoparticles. And reduces the interaction with the membrane. It was found that the ligand will bind to the membrane, a specific effect of moving into the cells, the nanoparticles of gold (3) nanoparticles of gold small to be able to move into the cells faster than nanoparticles of gold. The larger (4) gold nanoparticles that are small, they are likely to cause toxicity to the cells over a large gold nanoparticles. To study the interaction of gold nanoparticles with membrane will result in greater understanding. The chemical and physical properties of gold nanoparticles. The protective effect is due to the use of nanoparticles of various kinds in the future.