This notion of a continuum is in contrast to
the original Kraepelinian dichotomy between these syndromes.
However, an overlap of brain abnormalities in
schizophrenia and severe depression has been noted (34,
37, 38), and no particular abnormality has been found to
be pathognomonic for either disorder, including higher
ventricular brain ratios, which are also found prior to
brain injury in those who develop posttraumatic-braininjury
depression (39).