It is concluded from the study that extracts of algal strain used in the present investigation showed better antibacterial activity against the pathogens used, but further researches should be made to identify and purify natural product against antibacterial and antifungal. The enhanced antibacterial activity expressed in sequential extraction might be due to the fact that both hydrophobic and hydrophilic bioactive compounds were extracted. An improved knowledge of the composition, analysis, and properties of S. platensis with respect to antimicrobial compounds would assist in efforts for the pharmaceutical application of this cyanobacteria