Control system for chemical engineering processes has been developed continuously over a period. In the beginning, linear control theory is used to design a control system due to a limitation of computing technology. Currently, the advance of computing technologies play more important roles in the chemical processes as the result of new advanced control theories for complex chemical processes. Model-based control that is one of the advanced control theory were extensively studied during the past decades. Input-output (I/O) linearization is a one of the technique in differential geometric control (DGC) that is mainly focused. The principle of this technique associates with changing the relationship of dynamics nonlinear behavior between input and output to a linear relation (Henson, 1990; Kravaris, 1990; Kravaris, 1990). The I/O linearizing controller is the most popular technique in a group of DGC due to the advantage in proper set point tracking, guarantee closed-loop stability and least tuning parameters. However, this technique can be only applied in stable and minimum phase systems due to the inversion of the model dynamics made the stability of the closed-loop system. The controller formulated by using I/O linearization technique can be explained following