3.2.2. In vitro release study of GLS/A beads
It is well known that the pH in the GI tract varies from acidic to
slightly alkaline. Under empty stomach condition, the gastric pH value
of healthy adults is reported to be within pH 1 to 3, while the pH
changes from acid to almost neutral in the intestinal environment
[42]. In current study, the release of glucose from GLS/A beads as a function
of time was evaluated by incubation in a simulated stomach solution
(SS1, pH 1.8) followed by a simulated intestinal solution (SI1,