In traditional medicine, Aloe vera has been predominantly used for curative purposes in wound healing. Numerous scientific research had recently confirmed the efficiency of Aloe vera for healing many kinds of wounds, such as burn wound, wound in diabetic mellitus, oral ulcer, gastric ulcer, surgical wound, and radiation-induced wounds, etc. This review examines several scientific papers describing pharmacological effects, molecular mechanisms, and pharmaceutical preparations of Aloe vera in wound healing to serve as a scientific evidence for the potential of Aloe vera in wound healing. In the future, it might be possible to safely use this plant with same standard as those used in conventional medicine.