• 3.2 Vitamin B2 (riboflavin)
• Annual production of riboflavin is 4000 tons per year.
• Riboflavin overproducers include two yeastIlike molds, Eremothecium ashbyii and Ashbya gossypii, which synthesize
riboflavin in concentrations higher than 20 g/L.
• In A. gossypii, riboflavin production is stimulated three to fourfold by the precursors glycine and hypoxanthine. The level of
production occurs after growth rate declines.