Interventions to improve the QoL of patients with inhibitors are best handled by a multidisciplinary team approach that includes physicians, nurses, social workers, physical and occupational therapists, and psychologists. Clinical care includes the prevention and management of bleeding events and complications of bleeding, and regular exercise and visits to a physical therapist to maintain good joint health, slow or prevent the development of musculoskeletal complications, and mitigate chronic arthropathies and chronic pain.