However, many of these early methodological problems have since been overcome. The seminal study by Harrison et al.6 in Nottingham was the first study of its kind that was based on sound epidemiological principles, including prospective case finding within a defined catchment area, standardized assessments of mental state, operational diagnostic criteria, and extensive use of collateral history.7 They found that the incidence rate of schizophrenia was raised more than 12-fold in the African-Caribbean community, compared with the general population.
The seminal study
However, many of these early methodological problems have since been overcome. The seminal study by Harrison et al.6 in Nottingham was the first study of its kind that was based on sound epidemiological principles, including prospective case finding within a defined catchment area, standardized assessments of mental state, operational diagnostic criteria, and extensive use of collateral history.7 They found that the incidence rate of schizophrenia was raised more than 12-fold in the African-Caribbean community, compared with the general population.
The seminal study
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