CHARACTERISTICS OF ROS
Hydrogen peroxide (H2O2) is a weak oxidizing agent that is classified as a ROS because it can generate „OH
Transition metals (e.g. Fe2+ ) catalyze formation of the „OH from H2O2 in the Fenton reaction
H2O2 is lipid soluble, it can diffuse through membranes and generate „OH at localized Fe2+ or Cu+-containing sites (e.g. ETC within the mitochondria)