Three TPs were assigned to bezafibrate. Two TPs (an amideproduct (Bez 223) and 4-chlorobenzoic acid) resulting from the cleavage of the amide bond have been previously documented[10,18], whereas to our knowledge the third TP (Bez 238) has not been reported before. Bez 238 is also modified at the amide group and was predicted by UM-PPS as a second-generation TP. The pres-ence of a carboxyl-group is supported in the mass spectrum by afragment with a neutral CO2-loss (Fig. S3, Supplementary Material).