4. Discussion
In this study, probucol was administered to patients
with diabetic nephropathy, and these patients were
followed for 36 months or until initiation of hemodialysis.
During this period, urinary protein, serum
creatinine, and interval to initiation of hemodialysis
were evaluated. Blood glucose control, blood pressure
control and the amount of protein intake are known
factors affecting the progression of diabetic nephropathy.