As a result, gut microbiota–targeted therapies have become a new direction in the treatment of MAFLD (12-14). There are various ways to manipulate gut microbiota, among which probiotic supplementation is one of the most highly regarded to improve microbiome homeostasis. The most commonly used probiotics are Lactobacillus and Bifidobacterium, along with Lactococcus, Streptococcus, Enterococcus, and Bacillus. Because multiple clinical trials have shown that probiotic supplementation has definite therapeutic effects on MAFLD