since few years ago little data were availble about long-term effects of biologic therapy. in a recent study, nopp et al. reported that in patents with severe allergic asthma treated with anti-ige (xolair) for 6 years, asthma symptoms were mild or stable after 3 years since its withdrawal. intrinsic asthmatic patients are not treated with omalizumab even if the observation of a local ige production might favor the inverstigation of these drugs in this cohort of patients.