The analysis of positive selection revealed genes and associated BPs and MFs that showed significantly accelerated evolution in the Hexapoda and Collembola lineages. A substantial number of the enriched categories in both lineages are associated with ATP metabolism and ATPases activity. Ge et al. [77] showed that ATPase genes could be involved in the adaptation to the new environments due to their important role in energy provision as shown in mammalian adaptive evolution. A particular function for some ATPases is ionic transport over the cell membrane, which we discuss below